Silence Therapeutics: Of The Current Report On Form 8k Filed On December 15, 2025 (the “original Form 8k”) To Disclose Information Regarding Material Modifications To A Material Compensatory Plan, Contract Or Arrangement As To Which A Named Executive Officer Of The Registrant Participates That Were Effected Pursuant To An Agreement Entered Into Subsequent To The Filing Of The Original Form 8k. No Other Changes Have Been Made To The Original Form 8k

Item 5.02 of the Current Report on Form 8-K filed on December 15, 2025 (the “Original Form 8-K”) to disclose information regarding material modifications to a material compensatory plan, contract or arrangement as to which a named executive officer of the registrant participates that were effected pursuant to an agreement entered into subsequent to the filing of the Original Form 8-K. No other changes have been made to the Original Form 8-K.Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.As reported in the Original Form 8-K, effective as of December 14, 2025 (the “Separation Date”), Craig Tooman agreed by mutual consent to end his employment with Silence Therapeutics plc (the “Company”).On July 10, 2026, the Company and Mr. Tooman entered into a separation and release agreement (the “Separation Agreement”). Pursuant to the Separation Agreement, the Company will provide Mr. Tooman with (a) salary continuation for 12 months following the Separation Date for a total of $655,000, (b) a one-time lump sum cash severance payment of $250,000, (c) reimbursement of legal fees in the amount of $40,000 in connection with the negotiation and review of the Separation Agreement, (d) a lump sum bonus payment that Mr. Tooman would have otherwise earned in 2025 had he remained employed with the Company as of the Separation Date in the amount of $283,746.03, (e) reimbursement of healthcare premium in the amount of $46,896.48, (f) continued vesting of options granted under the Company’s 2023 Equity Incentive Plan (the “2023 Plan”) and the Company’s 2018 Long Term Incentive Plan (the “2018 Plan”) through 45 days following the Separation Date; (g) extended post-termination exercise period to up to 24 months after the Separation Date for any options granted to Mr. Tooman under the 2023 Plan (to the extent vested) and up to 12 months after the Separation Date for any options granted under the 2018 Plan (to the extent vested); and (h) acceleration of vesting of any unvested options upon a change of control event within 12 months following the Separation Date, subject to Mr. Tooman’s continued compliance with the Separation Agreement, and (i) up to $20,000 in payment for fees accrued to Mr. Tooman’s tax providers. The Separation Agreement also contains confidentiality, non-disparagement, non-solicitation and non-inference covenants and a release of claims by Mr. Tooman.The foregoing description of the terms of the Separation Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Separation Agreement, which the Company intends to file as an exhibit to its Quarterly Report on Form 10-Q for the quarter ended June 30, 2026. SIGNATURESPursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Silence Therapeutics plc Date: July 16, 2026 By: /s/ Rhonda Hellums Name:Rhonda Hellums Title: Chief Financial Officer

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